Brand  (β version)

PDB ID: 5ULI

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Ligands
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0WD [[(2r,3s,4r,5r)-5-(3-aminocarbonyl-4h-pyridin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate PoSSuM
CA Calcium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5ULI   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of mouse DXO in complex with (3'-NADP)+ and calcium ion
Release Data : 2017-05-17
Compound :
mol_id molecule chains synonym
1 Decapping and exoribonuclease protein A DXO,Dom-3 homolog Z
ec: 3.1.13.-,3.6.1.-
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:469008)
gene: Dxo, Dom3z, Ng6
expression_system_strain: BL21(DE3)Rosetta
expression_system_vector_type: plasmid
expression_system_plasmid: pet28a
Authors : Doamekpor, S.K., Tong, L.
Keywords : hydrolase, NADP
Exp. method : X-RAY DIFFRACTION ( 2.1000 Å )
Citation :

5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding.

Jiao, X.,Doamekpor, S.K.,Bird, J.G.  et al.
(2017)  Cell  168 : 1015 - 1027.e10

PubMed: 28283058
DOI: 10.1016/j.cell.2017.02.019

Reaction

Chain : A
UniProt : O70348 (DXO_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'- end phospho-ribonucleoside in mRNA + H(+) + NAD(+) - PubMed:28283058, PubMed:32374864
left-to-right PubMed:28283058
a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O = a 5'- end phospho-ribonucleoside in snoRNA + H(+) + NAD(+) - PubMed:28283058
left-to-right
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside- ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphospho- guanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+) - PubMed:23523372
left-to-right
a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+) - PubMed:32374864, PubMed:32432673
left-to-right PubMed:32432673
a 5'-end CoA-ribonucleoside in mRNA + H2O = 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+) - PubMed:32374864, PubMed:32432673
left-to-right PubMed:32432673