Het-PDB Navi2 (PDB: 5UJ3)

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Ligands
Code	Name		Style	Show	Link
CE4	(2r)-2-[(R)-{[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro -2h-1,3-thiazine-4-carboxylic acid				PoSSuM
GOL	Glycerol				PoSSuM

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Download interaction data: 5UJ3

Code :

5UJ3 PDBj RCSB PDB PDBe

Header :

HYDROLASE/ANTIBIOTIC

Title :

Crystal structure of the KPC-2 beta-lactamase complexed with hydrolyzed cefotaxime

Release Data :

2017-04-26

Compound :

mol_id	molecule	chains	synonym
1	Carbapenem-hydrolyzing beta-lactamase KPC	A	Carbapenem-hydrolyzing beta-lactamase KPC-1
	ec: 3.5.2.6

Source :

mol_id	organism_scientific	expression_system
1	Klebsiella pneumoniae (taxid:573)	Escherichia coli (taxid:469008)
	gene: bla, kpc, kpc1 expression_system_strain: BL21(DE3)

Authors :

Pemberton, O.A., Chen, Y.

Keywords :

carbapenemase, cefotaxime, beta-lactamase, complex, HYDROLASE-ANTIBIOTIC complex

Exp. method :

X-RAY DIFFRACTION ( 1.4500 Å )

Citation :

Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).

Pemberton, O.A.,Zhang, X.,Chen, Y.
(2017) J. Med. Chem. 60 : 3525 - 3530

Chain :

UniProt :

Q9F663 (BLKPC_KLEPN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PubMed:11257029, PubMed:33257320
a beta-lactam + H2O = a substituted beta-amino acid	-	PubMed:11257029, PubMed:33257320

PDB ID: 5UJ3