Het-PDB Navi2 (PDB: 5TYI)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
99Y	4-carboxy-D-phenylalanine
48V	{[(2r)-2,3-diamino-3-oxopropyl]sulfanyl}acetic acid

Glycosylation
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Modification
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Download interaction data: 5TYI

Code :

5TYI PDBj RCSB PDB PDBe

Header :

Signaling Protein/Peptide

Title :

Grb7 SH2 with bicyclic peptide containing pY mimetic

Release Data :

2017-11-15

Compound :

mol_id	molecule	chains	synonym
1	Growth factor receptor-bound protein 7	A,B,C,D	B47,Epidermal growth factor receptor GRB-7,GRB7 adapter protein

mol_id	molecule	chains
2	Peptide inhibitor	L,M,N,P

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: GRB7

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Watson, G.M., Wilce, M.C.J., Wilce, J.A.

Keywords :

SH2, inhibitor, bicyclic, Signaling Protein-Peptide complex

Exp. method :

X-RAY DIFFRACTION ( 2.150 Å )

Citation :

Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.

Watson, G.M.,Kulkarni, K.,Sang, J. et al.
(2017) J. Med. Chem. 60 : 9349 - 9359

PDB ID: 5TYI