Brand  (β version)

PDB ID: 5TVF

Hetero Atom Contents

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Ligands
Code Name Style Show Link
B3P 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol PoSSuM
CGQ 3-[C-[N'-(3-carbamimidoyl-benzylidenium)-hydrazino]-[[aminomethylidene]aminium]-iminomethyl]-benzamidinium PoSSuM
PUT 1,4-diaminobutane PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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PYR Pyruvic acid

Structure summary

Code : 5TVF   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with inhibitor CGP 40215
Release Data : 2017-01-11
Compound :
mol_id molecule chains
1 S-adenosylmethionine decarboxylase beta chain A,C
ec: 4.1.1.50
mol_id molecule chains
2 S-adenosylmethionine decarboxylase alpha chain B,D
ec: 4.1.1.50
mol_id molecule chains
3 S-adenosylmethionine decarboxylase proenzyme-like, putative E,F
ec: 4.1.1.50
Source :
mol_id organism_scientific expression_system
1 Trypanosoma brucei brucei (strain 927/4 GUTat10.1)  (taxid:185431) Escherichia coli  (taxid:511693)
strain: 927/4 GUTat10.1
gene: Tb927.6.4410, Tb927.6.4460
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: pETDuet-1
mol_id organism_scientific expression_system
2 Trypanosoma brucei brucei (strain 927/4 GUTat10.1)  (taxid:185431) Escherichia coli  (taxid:511693)
strain: 927/4 GUTat10.1
gene: Tb927.6.4410, Tb927.6.4460
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: pETDuet-1
mol_id organism_scientific expression_system
3 Trypanosoma brucei brucei (strain 927/4 GUTat10.1)  (taxid:185431) Escherichia coli  (taxid:511693)
strain: 927/4 GUTat10.1
gene: Tb927.6.4470
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: pETDuet-1
Authors : Phillips, M.A., Volkov, O.A., Chen, Z., Tomchick, D.R.
Keywords : AdoMetDC, CGP40215, decarboxylase, allostery, pseudoenzyme, prozyme, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.420 Å )
Citation :

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.

Volkov, O.A.,Kinch, L.,Ariagno, C.  et al.
(2016)  Elife  5

PubMed: 27977001
DOI: 10.7554/eLife.20198

Reaction

Chain : B, D
UniProt : Q587A7 (Q587A7_TRYB2)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3- (methylsulfanyl)propylamine 4.1.1.50 PIRNR:PIRNR001355
-
Chain : E, F
UniProt : Q587B3 (Q587B3_TRYB2)
Reaction : -