PDB ID: 5TUQ
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Structure summary
Code : | 5TUQ PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||||||||||||||
Title : | Crystal Structure of a 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione Inhibitor in Complex with HIV Reverse Transcriptase | ||||||||||||||||||||||||
Release Data : | 2017-06-28 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Kirby, K.A., Sarafianos, S.G. | ||||||||||||||||||||||||
Keywords : | HIV-1, REVERSE TRANSCRIPTASE, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.7050 Å ) | ||||||||||||||||||||||||
Citation : |
6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.
Tang, J.,Kirby, K.A.,Huber, A.D.
et al.
PubMed: 28182989 |
Reaction
Chain : | B | ||||||||||||||||||||||||
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UniProt : | P03366 (POL_HV1B1) | ||||||||||||||||||||||||
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