Brand  (β version)

PDB ID: 5TLH

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
MDN Methylenediphosphonic acid PoSSuM
RD2 [(6-hydroxynaphthalen-2-yl)methylene]bis(phosphonic acid) PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5TLH   PDBj   RCSB PDB   PDBe
Header : LYASE/INHIBITOR
Title : Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor 2-naphthol 6-bisphosphonate
Release Data : 2017-10-25
Compound :
mol_id molecule chains synonym
1 Fructose-bisphosphate aldolase A A,B,C,D Muscle-type aldolase
ec: 4.1.2.13
Source :
mol_id organism_scientific organism_common expression_system
1 Oryctolagus cuniculus  (taxid:9986) Rabbit Escherichia coli  (taxid:562)
gene: ALDOA
expression_system_strain: BL21(SI)
expression_system_vector_type: plasmid
expression_system_plasmid: pPB14
Authors : Heron, P.W., Sygusch, J.
Keywords : INHIBITOR, BISPHOSPHONATE, COMPLEX, ALDOLASE, LYASE, LYASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.2040 Å )
Citation :

Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase.

Heron, P.W.,Abellan-Flos, M.,Salmon, L.  et al.
(2018)  J.Med.Chem.  61 : 10558 - 10572

PubMed: 30418024
DOI: 10.1021/acs.jmedchem.8b01000

Reaction

Chain : A, B, C, D
UniProt : P00883 (ALDOA_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3- phosphate + dihydroxyacetone phosphate 4.1.2.13 PubMed:20129922, PubMed:2204832
left-to-right PubMed:20129922