Het-PDB Navi2 (PDB: 5TIJ)

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Ligands
Code	Name		Style	Show	Link
5TX	((3s,5s)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonic acid				PoSSuM
MG	Magnesium ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5TIJ

Code :

5TIJ PDBj RCSB PDB PDBe

Header :

LYASE/LYASE INHIBITOR

Title :

Structure of Human Enolase 2 with ((3S,5S)-1,5-dihydroxy-3-methyl-2-oxopyrrolidin-3-yl)phosphonate (purified enantiomer)

Release Data :

2017-10-18

Compound :

mol_id	molecule	chains	synonym
1	Gamma-enolase	A,B	2-phospho-D-glycerate hydro-lyase, Enolase 2, Neural enolase, Neuron-specific enolase, NSE
	ec: 4.2.1.11

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: ENO2 expression_system_strain: Rosetta 2 (DE3) pLysS expression_system_vector_type: plasmid expression_system_plasmid: pJL-H6

Authors :

Leonard, P.G., Muller, F.L.

Keywords :

enolase gamma, glycolysis, neuron specific enolase, carbohydrate metabolism, LYASE-LYASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.6340 Å )

Citation :

Eradication of ENO1-deleted Glioblastoma through Collateral Lethality

Lin, Y.H.,Satani, N.,Hammoudi, N. et al.
(2019) Biorxiv

Chain :

A, B

UniProt :

P09104 (ENOG_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate	4.2.1.11	-
(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate	-	-

PDB ID: 5TIJ