Het-PDB Navi2 (PDB: 5TD4)

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Non-standard Residues
Code	Name	Show
PCA	Pyroglutamic acid

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 5TD4

Code :

5TD4 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Starch binding sites on the Human pancreatic alpha amylase D300N variant complexed with an octaose substrate.

Release Data :

2016-11-02

Compound :

mol_id	molecule	chains	synonym
1	Pancreatic alpha-amylase	A	PA,1,4-alpha-D-glucan glucanohydrolase
	ec: 3.2.1.1 fragment: UNP residues 16-511 mutation: D300N

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Komagataella pastoris (taxid:4922)
	organ: Pancreas gene: AMY2A

Authors :

Caner, S., Brayer, G.D.

Keywords :

Amylase, Diabetes, Obesity, Glucosyl hydrolase, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.300 Å )

Citation :

Evaluation of the Significance of Starch Surface Binding Sites on Human Pancreatic alpha-Amylase.

Zhang, X.,Caner, S.,Kwan, E. et al.
(2016) Biochemistry 55 : 6000 - 6009

Chain :

UniProt :

P04746 (AMYP_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D- glucose units.	3.2.1.1	PubMed:10091666, PubMed:10769135, PubMed:11772019, PubMed:11914097
	-
Cofactor:	Evidence:	Note:
Ca(2+)	ECO:0000269 \| PubMed:10091666 ECO:0000269 \| PubMed:10769135 ECO:0000269 \| PubMed:11772019 ECO:0000269 \| PubMed:11914097 ECO:0000269 \| PubMed:8528071	Binds 1 Ca(2+) ion per subunit.
chloride	ECO:0000269 \| PubMed:10091666 ECO:0000269 \| PubMed:10769135 ECO:0000269 \| PubMed:11772019 ECO:0000269 \| PubMed:11914097 ECO:0000269 \| PubMed:8528071	Binds 1 Cl(-) ion per subunit.

PDB ID: 5TD4