Het-PDB Navi2 (PDB: 5T66)

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Ligands
Code	Name		Style	Show	Link
C6S	(3r)-3-(cyclohexylcarbonylamino)-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid				PoSSuM

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Download interaction data: 5T66

Code :

5T66 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal Structure of CTX-M-15 with 1C

Release Data :

2017-02-15

Compound :

mol_id	molecule	chains
1	Beta-lactamase	A,B
	ec: 3.5.2.6 other_details: Ser73 complexed to boronate 1C

Source :

mol_id	organism_scientific	expression_system
1	Klebsiella pneumoniae (taxid:573)	Escherichia coli BL21(DE3) (taxid:469008)
	gene: blaCTX-M-15 expression_system_vector_type: Plasmid expression_system_plasmid: pOPINF

Authors :

Cahill, S.T., Brem, J., McDonough, M.A., Schofield, C.J.

Keywords :

serine-beta-lactamase, hydrolase, boronate inhibitor

Exp. method :

X-RAY DIFFRACTION ( 1.951 Å )

Citation :

Cyclic Boronates Inhibit All Classes of beta-Lactamases.

Cahill, S.T.,Cain, R.,Wang, D.Y. et al.
(2017) Antimicrob. Agents Chemother. 61

Chain :

A, B

UniProt :

G3G192 (G3G192_KLEPN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	ARBA:ARBA00001526, RuleBase:RU361140
a beta-lactam + H2O = a substituted beta-amino acid	-	ARBA:ARBA00001526, RuleBase:RU361140

PDB ID: 5T66