Brand  (β version)

PDB ID: 5SYT

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Ligands
Code Name Style Show Link
C8E (hydroxyethyloxy)tri(ethyloxy)octane PoSSuM
CXE Pentaethylene glycol monodecyl ether PoSSuM
DMS Dimethyl sulfoxide PoSSuM
GOL Glycerol PoSSuM
PC1 1,2-diacyl-sn-glycero-3-phosphocholine PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
SO4 Sulfate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5SYT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE, MEMBRANE PROTEIN
Title : Crystal Structure of ZMPSTE24
Release Data : 2016-11-02
Compound :
mol_id molecule chains synonym
1 CAAX prenyl protease 1 homolog A Farnesylated proteins-converting enzyme 1, FACE-1, Prenyl protein-specific endoprotease 1, Zinc metalloproteinase Ste24 homolog
ec: 3.4.24.84
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Saccharomyces cerevisiae  (taxid:4932)
gene: ZMPSTE24, FACE1, STE24
expression_system_common: Yeast
expression_system_strain: BJ5460
expression_system_atcc_number: 208285
expression_system_vector_type: plasmid
Authors : Clark, K., Jenkins, J.L., Fedoriw, N., Dumont, M.E., Membrane Protein Structural Biology Consortium (MPSBC)
Keywords : Hydrolase, Membrane Protein, CaaX protease, zinc metalloprotease, STE24, isoprenylation, Structural Genomics, PSI-2, Protein Structure Initiative, Membrane Protein Structural Biology Consortium, MPSBC
Exp. method : X-RAY DIFFRACTION ( 2.0000 Å )
Citation :

Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors.

Clark, K.M.,Jenkins, J.L.,Fedoriw, N.  et al.
(2017)  Protein Sci.  26 : 242 - 257

PubMed: 27774687
DOI: 10.1002/pro.3074

Reaction

Chain : A
UniProt : O75844 (FACE1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids. 3.4.24.84 PubMed:33293369, PubMed:33315887
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