Brand  (β version)

PDB ID: 5QQS

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Ligands
Code Name Style Show Link
JHP 4-chloro-N-cyclopentyl-1-methyl-1h-pyrazole-3-carboxamide PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 5QQS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z275151340
Release Data : 2019-08-07
Compound :
mol_id molecule chains synonym
1 5-aminolevulinate synthase, erythroid-specific, mitochondrial B,A ALAS-E,5-aminolevulinic acid synthase 2,Delta-ALA synthase 2,Delta-aminolevulinate synthase 2
ec: 2.3.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: ALAS2, ALASE, ASB
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
Authors : Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
Keywords : SGC - Diamond I04-1 fragment screening, PanDDA, XChemExplorer, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.8500 Å )
Citation :

PanDDA analysis group deposition

Bezerra, G.A.,Foster, W.,Bailey, H.  et al.
To Be Published 

Reaction

Chain : B, A
UniProt : P22557 (HEM0_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA 2.3.1.37 PubMed:14643893, PubMed:21252495, PubMed:21309041, PubMed:21653323, PubMed:32499479, PubMed:34492704
left-to-right PubMed:14643893, PubMed:32499479
[Isoform 1]
succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA 		2.3.1.37 PubMed:14643893
left-to-right
[Isoform 3]
succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA 		2.3.1.37 PubMed:14643893
left-to-right
[Isoform 4]
succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA 		2.3.1.37 PubMed:14643893
left-to-right
Cofactor: Evidence: Note:
pyridoxal 5'-phosphate ECO:0000269 | PubMed:32499479
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