Het-PDB Navi2 (PDB: 5QQD)

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Ligands
Code	Name		Style	Show	Link
EDO	1,2-ethanediol				PoSSuM
JGA	N-ethyl-N'-(5-methyl-1,2-oxazol-3-yl)urea				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5QQD

Code :

5QQD PDBj RCSB PDB PDBe

Header :

Hydrolase/Transferase

Title :

PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with Z56880342

Release Data :

2019-12-18

Compound :

mol_id	molecule	chains	synonym
1	Ras-related C3 botulinum toxin substrate 1	A	Cell migration-inducing gene 5 protein,Ras-like protein TC25,p21-Rac1

mol_id	molecule	chains	synonym
2	Kalirin	B	Huntingtin-associated protein-interacting protein,Protein Duo,Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
	ec: 2.7.11.1 mutation: None

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: RAC1, TC25, MIG5

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: KALRN, DUET, DUO, HAPIP, TRAD

Authors :

Gray, J.L., Krojer, T., Talon, R., Douangamath, A., Jimenez Antunez, C., Bountra, C., Arrowsmith, C.H., Edwards, A., Brennan, P.E., von Delft, F.

Keywords :

SGC - Diamond I04-1 fragment screening, XChemExplorer, Hydrolase-Transferase complex

Exp. method :

X-RAY DIFFRACTION ( 1.9100 Å )

Citation :

PanDDA analysis group deposition

Gray, J.L.,Krojer, T.,Talon, R. et al.
To Be Published

Chain :

UniProt :

P63000 (RAC1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
GTP + H2O = GDP + phosphate + H(+)	3.6.5.2	PubMed:21565175
GTP + H2O = GDP + phosphate + H(+)	left-to-right	PubMed:21565175

Chain :

UniProt :

O60229 (KALRN_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.1	-
	-	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.1	-
	-	-
Cofactor:	Evidence:	Note:
Mg(2+)	-	-

PDB ID: 5QQD

Hetero Atom Contents

Structure summary

Reaction