Brand  (β version)

PDB ID: 5QOL

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
JGP (azepan-1-yl)(2h-1,3-benzodioxol-5-yl)methanone PoSSuM
Non-standard Residues
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Structure summary

Code : 5QOL   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with FMOPL000435a
Release Data : 2019-05-08
Compound :
mol_id molecule chains synonym
1 DCP2 (NUDT20) A Nucleoside diphosphate-linked moiety X motif 20, Nudix motif 20, mRNA-decapping enzyme 2, hDpc, m7GpppN-mRNA hydrolase
ec: 3.6.1.62
fragment: UNP residues 95-260
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DCP2, NUDT20
Authors : Nelson, E.R., Velupillai, S., Talon, R., Collins, P.M., Krojer, T., Wang, D., Brandao-Neto, J., Douangamath, A., Burgess-Brown, N., Arrowsmith, C.H., Bountra, C., Huber, K., von Delft, F.
Keywords : SGC - Diamond I04-1 fragment screening, PanDDA, XChemExplorer, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.8500 Å )
Citation :

PanDDA analysis group deposition

Nelson, E.R.,Velupillai, S.,Talon, R.  et al.
To Be Published 

Reaction

Chain : A
UniProt : Q8IU60 (DCP2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP 3.6.1.62 PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401
left-to-right PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401