Brand  (β version)

PDB ID: 5QIN

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
J2V N-{4-[3-(6-methoxypyridin-3-yl)-1h-pyrrolo[3,2-B]pyridin-2-yl]pyridin-2-yl}acetamide PoSSuM
MG Magnesium ion PoSSuM
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Structure summary

Code : 5QIN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN IN COMPLEX WITH N- {4-[3-(6-METHOXYPYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-2- YL]PYRIDIN-2-YL}ACETAMIDE
Release Data : 2018-10-31
Compound :
mol_id molecule chains synonym
1 TGF-beta receptor type-2 A TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TbetaR-II
ec: 2.7.11.30
fragment: KINASE DOMAIN, UNP RESIDUES 237-549
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human SPODOPTERA FRUGIPERDA  (taxid:7108)
gene: TGFBR2
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
expression_system_plasmid: PFASTBAC1
Authors : Sheriff, S.
Keywords : KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.5700 Å )
Citation :

Discovery of 4-Azaindole Inhibitors of TGF beta RI as Immuno-oncology Agents.

Zhang, Y.,Zhao, Y.,Tebben, A.J.  et al.
(2018)  ACS Med Chem Lett  9 : 1117 - 1122

PubMed: 30429955
DOI: 10.1021/acsmedchemlett.8b00357

Reaction

Chain : A
UniProt : P37173 (TGFR2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein] 2.7.11.30 -
-
ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein] 2.7.11.30 -
-