Het-PDB Navi2 (PDB: 5QIN)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name	Link
GOL	Glycerol	PoSSuM
J2V	N-{4-[3-(6-methoxypyridin-3-yl)-1h-pyrrolo[3,2-B]pyridin-2-yl]pyridin-2-yl}acetamide	PoSSuM
MG	Magnesium ion	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5QIN

Code :

5QIN PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN IN COMPLEX WITH N- {4-[3-(6-METHOXYPYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-2- YL]PYRIDIN-2-YL}ACETAMIDE

Release Data :

2018-10-31

Compound :

mol_id	molecule	chains	synonym
1	TGF-beta receptor type-2	A	TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TbetaR-II
	ec: 2.7.11.30 fragment: KINASE DOMAIN, UNP RESIDUES 237-549

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	SPODOPTERA FRUGIPERDA (taxid:7108)
	gene: TGFBR2 expression_system_common: Fall armyworm expression_system_vector_type: baculovirus expression_system_plasmid: PFASTBAC1

Authors :

Sheriff, S.

Keywords :

KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 1.5700 Å )

Citation :

Discovery of 4-Azaindole Inhibitors of TGF beta RI as Immuno-oncology Agents.

Zhang, Y.,Zhao, Y.,Tebben, A.J. et al.
(2018) ACS Med Chem Lett 9 : 1117 - 1122

Chain :

UniProt :

P37173 (TGFR2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl- [receptor-protein] + ADP + H(+)	2.7.11.30	-
	-	-
L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl- [receptor-protein] + ADP + H(+)	2.7.11.30	-
	-	-
Cofactor:	Evidence:	Note:
Mn(2+)	ECO:0000250 ECO:0000250	-

PDB ID: 5QIN