Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
GOL Glycerol
J2Y N-{4-[3-(5-methoxypyridin-2-yl)-1h-pyrrolo[3,2-B]pyridin-2-yl]pyridin-2-yl}acetamide
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 5QIM   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-{4-[3-(5-METHOXYPYRIDIN-2-YL)-1H-PYRROLO[3,2-B] PYRIDIN-2-YL]PYRIDIN-2-YL}ACETAMIDE
Release Data : 2018-10-31
Compound :
mol_id molecule chains synonym
1 TGF-beta receptor type-1 A TGFR-1,Activin A receptor type II-like protein kinase of 53kD,Activin receptor-like kinase 5,ALK5,Serine/threonine-protein kinase receptor R4,SKR4,TGF-beta type I receptor,Transforming growth factor-beta receptor type I,TbetaR-I
ec: 2.7.11.30
fragment: KINASE DOMAIN, UNP RESIDUES 200-503
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human SPODOPTERA FRUGIPERDA  (taxid:7108)
gene: TGFBR1, ALK5, SKR4
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
expression_system_plasmid: PFASTBAC1
Authors : Sheriff, S.
Keywords : ALK5, SB431542, KINASE DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.7500 Å )
Citation :

Discovery of 4-Azaindole Inhibitors of TGF beta RI as Immuno-oncology Agents.

Zhang, Y.,Zhao, Y.,Tebben, A.J.  et al.
(2018)  ACS Med Chem Lett  9 : 1117 - 1122

PubMed: 30429955
DOI: 10.1021/acsmedchemlett.8b00357

Chain : A
UniProt : P36897 (TGFR1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho- L-threonyl-[receptor-protein] 2.7.11.30 -
-
ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L- seryl-[receptor-protein] 2.7.11.30 -
-