Het-PDB Navi2 (PDB: 5Q19)

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Ligands
Code	Name		Style	Show	Link
9N1	(2s)-N,2-dicyclohexyl-2-[2-(2,4-dimethoxyphenyl)-1h-benzimidazol-1-yl]acetamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5Q19

Code :

5Q19 PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Ligand binding to FARNESOID-X-RECEPTOR

Release Data :

2017-07-05

Compound :

mol_id	molecule	chains	synonym
1	Bile acid receptor	A,C	Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14

mol_id	molecule	chains
2	COACTIVATOR PEPTIDE SRC-1 HD3	B,D
	fragment: UNP residues 744-757

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: NR1H4, BAR, FXR, HRR1, RIP14 expression_system_vector_type: PLASMID expression_system_plasmid: PET28A

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Rudolph, M.G., Benz, J., Burger, D., Thoma, R., Ruf, A., Joseph, C., Kuhn, B., Shao, C., Yang, H., Burley, S.K.

Keywords :

D3R, FXR, Docking, TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 1.9800 Å )

Citation :

D3R Grand Challenge 2: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies.

Gaieb, Z.,Liu, S.,Gathiaka, S. et al.
(2018) J. Comput. Aided Mol. Des. 32 : 1 - 20

Chain :

B, D

UniProt :

A8K1V4 (A8K1V4_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)	2.3.1.48	ARBA:ARBA00048017
	-	ARBA:ARBA00048017

PDB ID: 5Q19