Brand  (β version)

PDB ID: 5Q05

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Ligands
Code Name Style Show Link
95S N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide PoSSuM
Non-standard Residues
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Structure summary

Code : 5Q05   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase Inhibitor
Title : Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea
Release Data : 2019-01-09
Compound :
mol_id molecule chains synonym
1 Fructose-1,6-bisphosphatase 1 A,B,C,D,E,F,G,H Growth-inhibiting protein 17,cDNA FLJ75786,highly similar to Homo sapiens fructose-1,6-bisphosphatase 1 (FBP1),mRNA
ec: 3.1.3.11
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FBP1, hCG_1640493
Authors : Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M.G., Yang, H., Shao, C., Burley, S.K.
Keywords : D3R docking, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.2000 Å )
Citation :

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea

Ruf, A.,Joseph, C.,Alker, A.  et al.
To be published 

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : Q2TU34 (Q2TU34_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate 3.1.3.11 ARBA:ARBA00001273
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