Het-PDB Navi2 (PDB: 5OWT)

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Ligands
Code	Name	Link
F37	(5s)-5-methyl-5-[4-(4-oxidanylidene-3h-quinazolin-2-yl)phenyl]imidazolidine-2,4-dione	PoSSuM
SO4	Sulfate ion	PoSSuM
ZN	Zinc ion	PoSSuM

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Download interaction data: 5OWT

Code :

5OWT PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of TNKS2 in complex with (5S)-5-methyl-5-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]imidazolidine-2,4-dione

Release Data :

2018-05-02

Compound :

mol_id	molecule	chains	synonym
1	Tankyrase-2	A,B	TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
	ec: 2.4.2.30

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: TNKS2, PARP5B, TANK2, TNKL expression_system_variant: ROSETTA 2 expression_system_vector_type: Plasmid expression_system_plasmid: PNIC28-BSA4

Authors :

Nkizinkiko, Y., Haikarainen, T., Lehtio, L.

Keywords :

Tankyrase, Inhibitor, ARTD6, PARP5b, ADP-ribosyltransferase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.

Nkizinkiko, Y.,Desantis, J.,Koivunen, J. et al.
(2018) Sci Rep 8 : 1680 - 1680

PDB ID: 5OWT