Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
F37 (5s)-5-methyl-5-[4-(4-oxidanylidene-3h-quinazolin-2-yl)phenyl]imidazolidine-2,4-dione
SO4 Sulfate ion
ZN Zinc ion
Code : 5OWT
Header : TRANSFERASE
Title : Crystal structure of TNKS2 in complex with (5S)-5-methyl-5-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]imidazolidine-2,4-dione
Release Data : 2018-05-02
Compound :
mol_id molecule chains synonym
1 Tankyrase-2 A,B TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
ec: 2.4.2.30
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: TNKS2, PARP5B, TANK2, TNKL
expression_system_variant: ROSETTA 2
expression_system_vector_type: Plasmid
expression_system_plasmid: PNIC28-BSA4
Authors : Nkizinkiko, Y., Haikarainen, T., Lehtio, L.
Keywords : Tankyrase, Inhibitor, ARTD6, PARP5b, ADP-ribosyltransferase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.

Nkizinkiko, Y.,Desantis, J.,Koivunen, J.  et al.
(2018)  Sci Rep  8 : 1680 - 1680

PubMed: 29374194
DOI: 10.1038/s41598-018-19872-3

Chain : A, B
UniProt : Q9H2K2 (TNKS2_HUMAN)
Reaction : NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.