Brand  (β version)

PDB ID: 5OOI

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Ligands
Code Name Style Show Link
9YE 4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-B]indole-9,10-dione PoSSuM
EDO 1,2-ethanediol PoSSuM
NA Sodium ion PoSSuM
ACT Acetate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5OOI   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P
Release Data : 2017-12-27
Compound :
mol_id molecule chains synonym
1 Casein kinase II subunit alpha' A,B CK II alpha'
ec: 2.7.11.1
mutation: C336S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSNK2A2, CK2A2
Authors : Hochscherf, J., Lindenblatt, D., Witulski, B., Birus, R., Aichele, D., Marminon, C., Bouaziz, Z., Le Borgne, M., Jose, J., Niefind, K.
Keywords : protein kinase CK2, casein kinase 2, indenoindole-type inhibitors, transferase
Exp. method : X-RAY DIFFRACTION ( 1.998 Å )
Citation :

Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2 alpha and Its Paralog CK2 alpha '.

Hochscherf, J.,Lindenblatt, D.,Witulski, B.  et al.
(2017)  Pharmaceuticals (Basel)  10

PubMed: 29236079
DOI: 10.3390/ph10040098

Structure of the human protein kinase CK2 catalytic subunit CK2alpha' and interaction thermodynamics with the regulatory subunit CK2beta

Bischoff, N.,Olsen, B.,Raaf, J.  et al.
(2011)  J. Mol. Biol.  407 : 1 - 12

PubMed: 21241709
DOI: 10.1016/j.jmb.2011.01.020

Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.

Hundsdoerfer, C.,Hemmerling, H.J.,Goetz, C.  et al.
(2012)  Bioorg. Med. Chem.  20 : 2282 - 2289

PubMed: 22377675
DOI: 10.1016/j.bmc.2012.02.017

Reaction

Chain : A, B
UniProt : P19784 (CSK22_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:11239457, PubMed:20545769, PubMed:21482717, PubMed:30898438
left-to-right PubMed:11239457, PubMed:20545769, PubMed:21482717, PubMed:30898438, PubMed:35597237
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:22325354
left-to-right