Brand  (β version)

PDB ID: 5OO0

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Ligands
Code Name Style Show Link
9YZ Methyl 4-propanoyl-2,3-dihydroquinoxaline-1-carboxylate PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 5OO0   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Cdk2(WT) covalent adduct with D28 at C177
Release Data : 2018-03-14
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 2 A Cell division protein kinase 2,p33 protein kinase
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CDK2, CDKN2
Authors : Craven, G., Morgan, R.M.L., Mann, D.J.
Keywords : Covalent inhibitor, Cysteine modification, Kinase, Allosteric inhibitor, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.

Craven, G.B.,Affron, D.P.,Allen, C.E.  et al.
(2018)  Angew. Chem. Int. Ed. Engl.  57 : 5257 - 5261

PubMed: 29480525
DOI: 10.1002/anie.201711825

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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