Brand  (β version)

PDB ID: 5OMH

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Ligands
Code Name Style Show Link
9Y5 1-(3-chlorophenyl)-3-methyl-4~{H}-pyrazolo[4,3-C][1,2]benzothiazine 5,5-dioxide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5OMH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : p38alpha in complex with pyrazolobenzothiazine inhibitor COXH11
Release Data : 2019-03-13
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a
ec: 2.7.11.24
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Authors : Buehrmann, M., Rauh, D.
Keywords : p38, kinase, inhibitor, pyrazolobenzothiazine, complex, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38 alpha MAPK inhibitors.

Bartolini, D.,Buhrmann, M.,Barreca, M.L.  et al.
(2019)  Biochem.Biophys.Res.Commun.  511 : 579 - 586

PubMed: 30824186
DOI: 10.1016/j.bbrc.2019.02.063

Reaction

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right PubMed:11010976, PubMed:35857590