Brand  (β version)

PDB ID: 5OHT

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
9VH [(3~{S},4~{R},5~{R})-4,5-bis(oxidanyl)piperidin-3-yl]methanesulfonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5OHT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : A GH31 family sulfoquinovosidase from E. coli in complex with aza-sugar inhibitor IFGSQ
Release Data : 2018-08-08
Compound :
mol_id molecule chains synonym
1 Sulfoquinovosidase A,B SQase
ec: 3.2.1.199
Source :
mol_id organism_scientific expression_system
1 Escherichia coli (strain K12)  (taxid:83333) Escherichia coli BL21(DE3)  (taxid:469008)
gene: yihQ, squQ, b3878, JW3849
Authors : Jin, Y., Williams, S.J., Goddard-Borger, E., Davies, G.J.
Keywords : sulfoglycosidase, sulfoglycolysis, complex, general acid-base varient, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.8700 Å )
Citation :

Structural and Biochemical Insights into the Function and Evolution of Sulfoquinovosidases.

Abayakoon, P.,Jin, Y.,Lingford, J.P.  et al.
(2018)  ACS Cent Sci  4 : 1266 - 1273

PubMed: 30276262
DOI: 10.1021/acscentsci.8b00453

Reaction

Chain : A, B
UniProt : P32138 (SQASE_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O = 6-sulfo- alpha-D-quinovose + a 1,2-diacyl-sn-glycerol 3.2.1.199 PubMed:26878550
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3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O = 6-sulfo-alpha- D-quinovose + glycerol - PubMed:26878550, PubMed:30276262
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