Het-PDB Navi2 (PDB: 5OHJ)

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Ligands
Code	Name	Link
ZN	Zinc ion	PoSSuM
MG	Magnesium ion	PoSSuM
9VE	[(1~{S})-2-[3,5-bis(chloranyl)-1-oxidanyl-pyridin-1-ium-4-yl]-1-[4-[bis(fluoranyl)methoxy]-3-(cyclopropylmethoxy)phenyl]ethyl] (2~{S})-1-[3-(dimethylcarbamoyl)phenyl]sulfonylpyrrolidine-2-carboxylate	PoSSuM

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Download interaction data: 5OHJ

Code :

5OHJ PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Human phosphodiesterase 4B catalytic domain in complex with a pyrrolidinyl inhibitor.

Release Data :

2017-12-13

Compound :

mol_id	molecule	chains	synonym
1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	A,B	DPDE4,PDE32
	ec: 3.1.4.53

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: PDE4B, DPDE4 expression_system_common: Fall armyworm expression_system_cell_line: Sf9 expression_system_vector_type: Baculovirus expression_system_plasmid: pFastbac1:PDE4B UCR

Authors :

Rizzi, A., Carzaniga, L., Armani, E.

Keywords :

human phosphodiesterase 4B, hydrolase, pyrrolidinyl inhibitor, PDE4B

Exp. method :

X-RAY DIFFRACTION ( 1.60 Å )

Citation :

Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases.

Carzaniga, L.,Amari, G.,Rizzi, A. et al.
(2017) J. Med. Chem. 60 : 10026 - 10046

Chain :

A, B

UniProt :

Q07343 (PDE4B_HUMAN)

PDB ID: 5OHJ