Brand  (β version)

PDB ID: 5OGC

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
9V5 4-chloranyl-2-nitro-1-(phenylsulfonyl)benzene PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
TA1 Taxol PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 5OGC   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : Molecular basis of human kinesin-8 function and inhibition
Release Data : 2017-10-25
Compound :
mol_id molecule chains synonym
1 Kinesin-like protein KIF18A K Marrow stromal KIF18A,MS-KIF18A
mol_id molecule chains
2 Tubulin alpha chain A
mol_id molecule chains synonym
3 Tubulin beta chain B Beta-tubulin
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: KIF18A, OK/SW-cl.108
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Bovine
mol_id organism_scientific organism_common
3 Sus scrofa  (taxid:9823) Pig
Authors : Locke, J., Joseph, A.P., Topf, M., Moores, C.A.
Keywords : Cytoskeleton, Motor protein, Kinesin, TRANSPORT PROTEIN
Exp. method : ELECTRON MICROSCOPY ( 4.8 Å )
Citation :

Structural basis of human kinesin-8 function and inhibition.

Locke, J.,Joseph, A.P.,Pena, A.  et al.
(2017)  Proc. Natl. Acad. Sci. U.S.A.  114 : E9539 - E9548

PubMed: 29078367
DOI: 10.1073/pnas.1712169114

Reaction

Chain : K
UniProt : Q8NI77 (KI18A_HUMAN)
Reaction : -
Chain : A
UniProt : F2Z4C1 (F2Z4C1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - ARBA:ARBA00049117
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000256 | ARBA:ARBA00001946
-
Chain : B
UniProt : P02554 (TBB_PIG)
Reaction : -
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-