Het-PDB Navi2 (PDB: 5OFW)

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Ligands
Code	Name		Style	Show	Link
9TW	3-chloranyl-4-fluoranyl-benzamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5OFW

Code :

5OFW PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-Chloro-4-fluorobenzamide

Release Data :

2017-08-16

Compound :

mol_id	molecule	chains	synonym
1	D-3-phosphoglycerate dehydrogenase	B,A	3-PGDH,2-oxoglutarate reductase,Malate dehydrogenase
	ec: 1.1.1.95,1.1.1.399,1.1.1.37

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PHGDH, PGDH3

Authors :

Unterlass, J.E., Basle, A., Blackburn, T.J., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.

Keywords :

dehydrogenase, serine metabolism, FBDD, oxidoreductase

Exp. method :

X-RAY DIFFRACTION ( 1.50 Å )

Citation :

Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.

Unterlass, J.E.,Basle, A.,Blackburn, T.J. et al.
(2018) Oncotarget 9 : 13139 - 13153

Chain :

B, A

UniProt :

O43175 (SERA_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)	1.1.1.95	PubMed:11751922
	-	PubMed:11751922
(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)	1.1.1.399	PubMed:25406093
	-	PubMed:25406093
(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)	1.1.1.37	PubMed:25406093
(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)	-	PubMed:25406093

PDB ID: 5OFW