Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
9TW 3-chloranyl-4-fluoranyl-benzamide
Code : 5OFW
Header : OXIDOREDUCTASE
Title : Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-Chloro-4-fluorobenzamide
Release Data : 2017-08-16
Compound :
mol_id molecule chains synonym
1 D-3-phosphoglycerate dehydrogenase B,A 3-PGDH,2-oxoglutarate reductase,Malate dehydrogenase
ec: 1.1.1.95,1.1.1.399,1.1.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PHGDH, PGDH3
Authors : Unterlass, J.E., Basle, A., Blackburn, T.J., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.
Keywords : dehydrogenase, serine metabolism, FBDD, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.

Unterlass, J.E.,Basle, A.,Blackburn, T.J.  et al.
(2018)  Oncotarget  9 : 13139 - 13153

PubMed: 29568346
DOI: 10.18632/oncotarget.11487

Chain : B, A
UniProt : O43175 (SERA_HUMAN)
Reaction : 3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH.
(R)-2-hydroxyglutarate + NAD(+) = 2- oxoglutarate + NADH.
(S)-malate + NAD(+) = oxaloacetate + NADH.