Het-PDB Navi2 (PDB: 5OFV)

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Ligands
Code	Name		Style	Show	Link
9TZ	5-fluoranyl-2-methyl-benzoic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5OFV

Code :

5OFV PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 5-fluoro-2-methylbenzoic acid

Release Data :

2017-08-16

Compound :

mol_id	molecule	chains	synonym
1	D-3-phosphoglycerate dehydrogenase	B,A	3-PGDH,2-oxoglutarate reductase,Malate dehydrogenase
	ec: 1.1.1.95,1.1.1.399,1.1.1.37

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PHGDH, PGDH3

Authors :

Unterlass, J.E., Basle, A., Blackburn, T.J., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J.

Keywords :

dehydrogenase, serine metabolism, FBDD, oxidoreductase

Exp. method :

X-RAY DIFFRACTION ( 1.5 Å )

Citation :

Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.

Unterlass, J.E.,Basle, A.,Blackburn, T.J. et al.
(2018) Oncotarget 9 : 13139 - 13153

PDB ID: 5OFV