Het-PDB Navi2 (PDB: 5OF0)

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Ligands
Code	Name	Link
9TB	(2~{S})-2-[[(2~{S})-6-[(4-fluorophenyl)methylamino]-1-oxidanyl-1,6-bis(oxidanylidene)hexan-2-yl]carbamoylamino]pentanedioic acid	PoSSuM
CA	Calcium ion	PoSSuM
CL	Chloride ion	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
BMA	Beta-D-mannopyranose
MAN	Alpha-D-mannopyranose
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 5OF0

Code :

5OF0 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

X-ray structure of human glutamate carboxypeptidase II (GCPII), the E424M inactive mutant, in complex with a inhibitor CFBzOG

Release Data :

2018-08-01

Compound :

mol_id	molecule	chains	synonym
1	Glutamate carboxypeptidase 2	A	Cell growth-inhibiting gene 27 protein,Folate hydrolase 1,Folylpoly-gamma-glutamate carboxypeptidase,FGCP,Glutamate carboxypeptidase II,GCPII,Membrane glutamate carboxypeptidase,mGCP,N-acetylated-alpha-linked acidic dipeptidase I,NAALADase I,Prostate-specific membrane antigen,PSMA,Pteroylpoly-gamma-glutamate carboxypeptidase
	ec: 3.4.17.21 mutation: E424M

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Drosophila melanogaster (taxid:7227)
	gene: FOLH1, FOLH, NAALAD1, PSM, PSMA, GIG27 expression_system_cell_line: Schneiders S2 cells expression_system_vector_type: plasmid

Authors :

Novakova, Z., Motlova, L., Barinka, C.

Keywords :

glutamate carboxypeptidase II (GCPII); NAALADase; prostate-specific membrane antigen; urea based inhibitor, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.48 Å )

Citation :

2-Aminoadipic Acid-C(O)-Glutamate Based Prostate-Specific Membrane Antigen Ligands for Potential Use as Theranostics.

Nakajima, R.,Novakova, Z.,Tueckmantel, W. et al.
(2018) ACS Med Chem Lett 9 : 1099 - 1104

Chain :

UniProt :

Q04609 (FOLH1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.	3.4.17.21	-
	-	-
Cofactor:	Evidence:	Note:
Zn(2+)	ECO:0000269 \| PubMed:16467855 ECO:0000269 \| PubMed:17372356 ECO:0000269 \| PubMed:17567119 ECO:0000269 \| PubMed:18234225 ECO:0000269 \| PubMed:19053759 ECO:0000269 \| PubMed:19301871	Binds 2 Zn(2+) ions per subunit. Required for NAALADase activity.

PDB ID: 5OF0