PDB ID: 5OEW
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Code | Name | Style | Show | Link | |
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GLU | Glutamic acid | PoSSuM | |||
ZN | Zinc ion | PoSSuM | |||
ACT | Acetate ion | PoSSuM | |||
9TE | 4-cyclopropyl-7-(3-methoxyphenoxy)-2,3-dihydro-1$L^{6},2,4-benzothiadiazine 1,1-dioxide | PoSSuM |
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Download interaction data: 5OEW
Structure summary
Code : | 5OEW PDBj RCSB PDB PDBe | ||||||||||||
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Header : | MEMBRANE PROTEIN | ||||||||||||
Title : | Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with glutamate and positive allosteric modulator BPAM538 | ||||||||||||
Release Data : | 2018-01-03 | ||||||||||||
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Authors : | Larsen, A.P., Frydenvang, K.A., Kastrup, J.S. | ||||||||||||
Keywords : | Ionotropic glutamate receptor GluA2. ligand-binding domain, positive allosteric modulator, MEMBRANE PROTEIN | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.0000 Å ) | ||||||||||||
Citation : |
7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency.
Goffin, E.,Drapier, T.,Larsen, A.P.
et al.
PubMed: 29256599 Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold.
Norholm, A.B.,Francotte, P.,Olsen, L.
et al.
PubMed: 24131202 |
Reaction
Chain : | A, B, C |
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UniProt : | P19491 (GRIA2_RAT) |
Reaction : | - |