Het-PDB Navi2 (PDB: 5OCI)

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Ligands
Code	Name		Style	Show	Link
9R8	6-hydroxy-3-(3-methyl-benzyl)-1h-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5OCI

Code :

5OCI PDBj RCSB PDB PDBe

Header :

CHAPERONE

Title :

Human Heat Shock Protein 90 bound to 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide

Release Data :

2018-05-23

Compound :

mol_id	molecule	chains	synonym
1	Heat shock protein HSP 90-alpha	A	Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: HSP90AA1, HSP90A, HSPC1, HSPCA

Authors :

Schuetz, D.A., Richter, L., Amaral, M., Grandits, M., Musil, D., Graedler, U., Frech, M., Ecker, G.F.

Keywords :

HEAT-SHOCK PROTEIN COMPLEX, HSP90, ATPASE, PYRAZOLE, CHAPERONE, ATP-BINDING, HEAT SHOCK, NUCLEOTIDE-BINDING, PHOSPHORYLATION

Exp. method :

X-RAY DIFFRACTION ( 1.62 Å )

Citation :

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.

Schuetz, D.A.,Richter, L.,Amaral, M. et al.
(2018) J. Med. Chem. 61 : 4397 - 4411

Chain :

UniProt :

P07900 (HS90A_HUMAN)

PDB ID: 5OCI