Brand  (β version)

PDB ID: 5OCE

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Ligands
Code Name Style Show Link
PLM Palmitic acid PoSSuM
BMA Beta-D-mannopyranose PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5OCE   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : THE MOLECULAR MECHANISM OF SUBSTRATE RECOGNITION AND CATALYSIS OF THE MEMBRANE ACYLTRANSFERASE PatA -- Complex of PatA with palmitate, mannose, and palmitoyl-6-mannose
Release Data : 2017-12-27
Compound :
mol_id molecule chains synonym
1 Phosphatidylinositol mannoside acyltransferase A,B,C,D PIM acyltransferase
ec: 2.3.1.-
Source :
mol_id organism_scientific expression_system
1 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)  (taxid:246196) Mycobacterium smegmatis  (taxid:1772)
gene: MSMEG_2934, MSMEI_2860
Authors : Albesa-Jove, D., Tersa, M., Guerin, M.E.
Keywords : acyltransferase, glycolipid biosynthesis, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.41 Å )
Citation :

The Molecular Mechanism of Substrate Recognition and Catalysis of the Membrane Acyltransferase PatA from Mycobacteria.

Tersa, M.,Raich, L.,Albesa-Jove, D.  et al.
(2018)  ACS Chem. Biol.  13 : 131 - 140

PubMed: 29185694
DOI: 10.1021/acschembio.7b00578

Reaction

Chain : A, B, C, D
UniProt : A0QWG5 (ACYLT_MYCS2)
Reaction: EC: Evidence:
Physiological Direction:
a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo- inositol + an acyl-CoA = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha- D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA 2.3.1.265 PubMed:24810911
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a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl- (1<->6)-D-myo-inositol] + an acyl-CoA = a 1,2-diacyl-sn-glycero-3- phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA 2.3.1.265 PubMed:24810911
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