Het-PDB Navi2 (PDB: 5OCA)

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Ligands
Code	Name		Link
NA	Sodium ion		PoSSuM
TWA	2,3,4-tri-O-sulfo-beta-D-altropyranose		PoSSuM
TWD	2,3-di-O-sulfo-alpha-L-glucopyranose		PoSSuM
		: Polysaccharide

Non-standard Residues
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Glycosylation
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Download interaction data: 5OCA

Code :

5OCA PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

PCSK9:Fab Complex with Dextran Sulfate

Release Data :

2017-09-20

Compound :

mol_id	molecule	chains	synonym
1	Proprotein convertase subtilisin/kexin type 9	A	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
	ec: 3.4.21.-

mol_id	molecule	chains	synonym
2	Proprotein convertase subtilisin/kexin type 9	B	Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
	ec: 3.4.21.-

mol_id	molecule	chains
3	Fab from LDLR competitive antibody: Heavy chain	H

mol_id	molecule	chains
4	Fab from LDLR competitive antibody: Light chain	L

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Trichoplusia ni (taxid:7111)
	gene: PCSK9, NARC1, PSEC0052 expression_system_common: Cabbage looper

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Trichoplusia ni (taxid:7111)
	gene: PCSK9, NARC1, PSEC0052 expression_system_common: Cabbage looper

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

mol_id	organism_scientific	organism_common	expression_system
4	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

Authors :

Thirup, S.S., Vilstrup, J.P.

Keywords :

HYDROLASE, PROTEIN FAB COMPLEX, AUTOCATALYTIC CLEAVAGE, CHOLESTEROL METABOLISM, DISEASE MUTATION, DISULFIDE BOND, GLYCOPROTEIN, LIPID METABOLISM, PHOSPHOPROTEIN, PROTEASE, SECRETED, SERINE PROTEASE, STEROID METABOLISM, ZYMOGEN, HYDROLASE-IMMUNE SYSTEM COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.300 Å )

Citation :

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.

Gustafsen, C.,Olsen, D.,Vilstrup, J. et al.
(2017) Nat Commun 8 : 503 - 503

PubMed: 28894089
DOI: 10.1038/s41467-017-00568-7

Chain :

UniProt :

Q8NBP7 (PCSK9_HUMAN)

Cofactor:	Evidence:	Note:
Reaction :	-
Ca(2+)	ECO:0000305	-

PDB ID: 5OCA

Hetero Atom Contents

Structure summary

Reaction