Brand  (β version)

PDB ID: 5OCA

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Ligands
Code Name Style Show Link
NA Sodium ion PoSSuM
TWA 2,3,4-tri-O-sulfo-beta-D-altropyranose PoSSuM
TWD 2,3-di-O-sulfo-alpha-L-glucopyranose PoSSuM
: Polysaccharide
Non-standard Residues
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Structure summary

Code : 5OCA   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : PCSK9:Fab Complex with Dextran Sulfate
Release Data : 2017-09-20
Compound :
mol_id molecule chains synonym
1 Proprotein convertase subtilisin/kexin type 9 A Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
ec: 3.4.21.-
mol_id molecule chains synonym
2 Proprotein convertase subtilisin/kexin type 9 B Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9
ec: 3.4.21.-
mol_id molecule chains
3 Fab from LDLR competitive antibody: Heavy chain H
mol_id molecule chains
4 Fab from LDLR competitive antibody: Light chain L
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: PCSK9, NARC1, PSEC0052
expression_system_common: Cabbage looper
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: PCSK9, NARC1, PSEC0052
expression_system_common: Cabbage looper
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Thirup, S.S., Vilstrup, J.P.
Keywords : HYDROLASE, PROTEIN FAB COMPLEX, AUTOCATALYTIC CLEAVAGE, CHOLESTEROL METABOLISM, DISEASE MUTATION, DISULFIDE BOND, GLYCOPROTEIN, LIPID METABOLISM, PHOSPHOPROTEIN, PROTEASE, SECRETED, SERINE PROTEASE, STEROID METABOLISM, ZYMOGEN, HYDROLASE-IMMUNE SYSTEM COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.300 Å )
Citation :

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.

Gustafsen, C.,Olsen, D.,Vilstrup, J.  et al.
(2017)  Nat Commun  8 : 503 - 503

PubMed: 28894089
DOI: 10.1038/s41467-017-00568-7

Reaction

Chain : B
UniProt : Q8NBP7 (PCSK9_HUMAN)
Reaction : -