Het-PDB Navi2 (PDB: 5OC8)

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Ligands
Code	Name		Style	Show	Link
9QW	(4~{S})-5-(5-chloranyl-1-methyl-2-oxidanylidene-pyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4~{H}-pyrrolo[3,4-D]imidazol-6-one				PoSSuM
CL	Chloride ion				PoSSuM

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Download interaction data: 5OC8

Code :

5OC8 PDBj RCSB PDB PDBe

Header :

LIGASE

Title :

HDM2 (17-111, WILD TYPE) COMPLEXED WITH NVP-HDM201 AT 1.56A

Release Data :

2018-08-22

Compound :

mol_id	molecule	chains	synonym
1	E3 ubiquitin-protein ligase Mdm2	A	Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2
	ec: 2.3.2.27 fragment: N-terminal domain, p53 binding domain

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: MDM2 expression_system_vector_type: plasmid expression_system_plasmid: pET28-derived vector

Authors :

Kallen, J.

Keywords :

PPI WITH P53, INHIBITOR COMPLEX, CELL CYCLE, LIGASE

Exp. method :

X-RAY DIFFRACTION ( 1.5600 Å )

Citation :

Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201.

Jeay, S.,Ferretti, S.,Holzer, P. et al.
(2018) Cancer Res. 78 : 6257 - 6267

Chain :

UniProt :

Q00987 (MDM2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.	2.3.2.27	PubMed:12821780
	-	PubMed:12821780

PDB ID: 5OC8