PDB ID: 5OBR
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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9QT | 2-(3-chloranyl-5-fluoranyl-phenyl)quinoline-4-carboxylic acid | PoSSuM | |||
MG | Magnesium ion | PoSSuM | |||
SKE | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | PoSSuM |
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Download interaction data: 5OBR
Structure summary
Code : | 5OBR PDBj RCSB PDB PDBe | ||||||||||||
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Header : | CELL CYCLE | ||||||||||||
Title : | Aurora A kinase in complex with 2-(3-chloro-5-fluorophenyl)quinoline-4-carboxylic acid and JNJ-7706621 | ||||||||||||
Release Data : | 2017-08-09 | ||||||||||||
Compound : |
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Source : |
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Authors : | Rossmann, M., Janecek, M., Hyvonen, M. | ||||||||||||
Keywords : | inhibitor, kinase, allostery, protein-protein interface, CELL CYCLE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.620 Å ) | ||||||||||||
Citation : |
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.
Cole, D.J.,Janecek, M.,Stokes, J.E.
et al.
PubMed: 28787041 Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.
Janecek, M.,Rossmann, M.,Sharma, P.
et al.
PubMed: 27339427 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | O14965 (AURKA_HUMAN) | ||||||||||||
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