Brand  (β version)

PDB ID: 5O91

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Ligands
Code Name Style Show Link
C5N ~{N}-(2,6-diethylphenyl)-8-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1-methyl-4,5-dihydropyrazolo[4,3-H]quinazoline-3-carboxamide PoSSuM
EDO 1,2-ethanediol PoSSuM
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Structure summary

Code : 5O91   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human Mps1 (TTK) C604W mutant in complex with Cpd-5
Release Data : 2017-07-26
Compound :
mol_id molecule chains synonym
1 Dual specificity protein kinase TTK A Phosphotyrosine picked threonine-protein kinase,PYT
ec: 2.7.12.1
mutation: C604W
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TTK, MPS1, MPS1L1
Authors : Hiruma, Y., Joosten, R.P., Perrakis, A.
Keywords : Mps1, TTK, kinase, inhibitor, Cpd-5, mutant, C604W, transferase
Exp. method : X-RAY DIFFRACTION ( 3.2000 Å )
Citation :

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.

Hiruma, Y.,Koch, A.,Hazraty, N.  et al.
(2017)  J. Biol. Chem.  292 : 14496 - 14504

PubMed: 28726638
DOI: 10.1074/jbc.M117.783555

Reaction

Chain : A
UniProt : P33981 (TTK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.12.1 PubMed:30785839, PubMed:29162720
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.12.1 PubMed:29162720
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.12.1 PubMed:29162720
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