Het-PDB Navi2 (PDB: 5O8V)

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Ligands
Code	Name		Style	Show	Link
9O2	~{N}-[3-[7-azanyl-4-(2-phenylethylamino)quinazolin-2-yl]phenyl]propanamide				PoSSuM

Non-standard Residues
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Download interaction data: 5O8V

Code :

5O8V PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Covalent Inhibitor 4a bound to the Lipid Pocket of p38alpha Mutant S251C

Release Data :

2017-09-06

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 14	A	MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a
	ec: 2.7.11.24

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A

Authors :

Buehrmann, M., Rauh, D.

Keywords :

kinase, small molecule, lipid pocket, p38, covalent, mutant, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Covalent Lipid Pocket Ligands Targeting p38 alpha MAPK Mutants.

Buhrmann, M.,Hardick, J.,Weisner, J. et al.
(2017) Angew. Chem. Int. Ed. Engl. 56 : 13232 - 13236

Chain :

UniProt :

Q16539 (MK14_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.24	PubMed:11010976, PubMed:35857590
	left-to-right	PubMed:11010976, PubMed:35857590
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.24	PubMed:11010976, PubMed:35857590
	left-to-right	PubMed:11010976, PubMed:35857590

PDB ID: 5O8V