Brand  (β version)

PDB ID: 5O7I

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Ligands
Code Name Style Show Link
9N8 4-(2-bromanyl-6-fluoranyl-phenyl)carbonyl-~{N}-pyridin-3-yl-1~{H}-pyrrole-2-carboxamide PoSSuM
DMS Dimethyl sulfoxide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5O7I   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : ERK5 in complex with a pyrrole inhibitor
Release Data : 2018-06-20
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 7 A MAPK 7,Big MAP kinase 1,BMK-1,Extracellular signal-regulated kinase 5,ERK-5
ec: 2.7.11.24
fragment: UNP residues 46-402
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: MAPK7, BMK1, ERK5, PRKM7
expression_system_common: Fall armyworm
expression_system_cell_line: Sf9
expression_system_plasmid: pFastBac HT A
Authors : Tucker, J.A., Heptinstall, A., Myers, S.
Keywords : KINASE, INHIBITOR, PYRROLE, transferase
Exp. method : X-RAY DIFFRACTION ( 2.38 Å )
Citation :

Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38 alpha and BRD4.

Myers, S.M.,Miller, D.C.,Molyneux, L.  et al.
(2019)  Eur.J.Med.Chem.  178 : 530 - 543

PubMed: 31212132
DOI: 10.1016/j.ejmech.2019.05.057

Reaction

Chain : A
UniProt : Q13164 (MK07_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.24 -
-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.24 -
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250
-