Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
9MK (4-fluoranyl-3-oxidanyl-phenyl)-(6-methylquinolin-2-yl)methanone
BGC Beta-D-glucose
NA Sodium ion
NAD Nicotinamide-adenine-dinucleotide
Code : 5O6X
Header : OXIDOREDUCTASE
Title : 17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal quinoline based inhibitor
Release Data : 2018-06-06
Compound :
mol_id molecule chains synonym
1 17-beta-hydroxysteroid dehydrogenase 14 A 17-beta-HSD 14,17-beta-hydroxysteroid dehydrogenase DHRS10,Dehydrogenase/reductase SDR family member 10,Retinal short-chain dehydrogenase/reductase retSDR3,Short chain dehydrogenase/reductase family 47C member 1
ec: 1.1.1.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
gene: HSD17B14, DHRS10, SDR3, SDR47C1, UNQ502/PRO474
expression_system_variant: pLysS
Authors : Bertoletti, N., Braun, F., Heine, A., Klebe, G., Marchais-Oberwinkler, S.
Keywords : non-steroidal inhibitor, 17beta-HSD14, 2, 6-pyridinketone inhibitors, Oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 1.350 Å )
Citation :

Structure-based design and profiling of novel 17 beta-HSD14 inhibitors.

Braun, F.,Bertoletti, N.,Moller, G.  et al.
(2018)  Eur J Med Chem  155 : 61 - 76

PubMed: 29859505
DOI: 10.1016/j.ejmech.2018.05.029

Chain : A
UniProt : Q9BPX1 (DHB14_HUMAN)
Reaction : -