Brand  (β version)

PDB ID: 5O6H

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Ligands
Code Name Style Show Link
MYA Tetradecanoyl-CoA PoSSuM
PO4 Phosphate ion PoSSuM
9M2 1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine PoSSuM
MG Magnesium ion PoSSuM
GOL Glycerol PoSSuM
DMS Dimethyl sulfoxide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5O6H   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-917
Release Data : 2018-05-16
Compound :
mol_id molecule chains synonym
1 Glycylpeptide N-tetradecanoyltransferase 1 A,B Myristoyl-CoA:protein N-myristoyltransferase 1,Type I N-myristoyltransferase,Peptide N-myristoyltransferase 1
ec: 2.3.1.97
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: NMT1, NMT
expression_system_variant: pRareS
Authors : Brannigan, J.A., Wilkinson, A.J.
Keywords : Myristoyl, transferase, inhibitor
Exp. method : X-RAY DIFFRACTION ( 1.29 Å )
Citation :

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.

Mousnier, A.,Bell, A.S.,Swieboda, D.P.  et al.
(2018)  Nat Chem  10 : 599 - 606

PubMed: 29760414
DOI: 10.1038/s41557-018-0039-2

Reaction

Chain : A, B
UniProt : P30419 (NMT1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein] 2.3.1.97 PubMed:22865860, PubMed:25255805, PubMed:32103017, PubMed:32111831, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952
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N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] - PubMed:32103017, PubMed:32111831
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