Brand  (β version)

PDB ID: 5O5R

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Ligands
Code Name Style Show Link
9OQ (2~{S})-2-[[(2~{S})-6-[[(2~{S})-2-[[4-[[[(2~{R})-2-[[(2~{R})-2-[(6-fluoranylpyridin-3-yl)carbonylamino]-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]methyl]phenyl]carbonylamino]-3-naphthalen-2-yl-propanoyl]amino]-1-oxidanyl-1-oxidanylidene-hexan-2-yl]carbamoylamino]pentanedioic acid PoSSuM
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
EDO 1,2-ethanediol PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
FUC Alpha-L-fucopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 5O5R   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a urea based inhibitor PSMA 1023
Release Data : 2018-06-13
Compound :
mol_id molecule chains synonym
1 Glutamate carboxypeptidase 2 A Cell growth-inhibiting gene 27 protein,Folate hydrolase 1,Folylpoly-gamma-glutamate carboxypeptidase,FGCP,Glutamate carboxypeptidase II,GCPII,Membrane glutamate carboxypeptidase,mGCP,N-acetylated-alpha-linked acidic dipeptidase I,NAALADase I,Prostate-specific membrane antigen,PSMA,Pteroylpoly-gamma-glutamate carboxypeptidase
ec: 3.4.17.21
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Drosophila melanogaster  (taxid:7227)
gene: FOLH1, FOLH, NAALAD1, PSM, PSMA, GIG27
expression_system_common: Fruit fly
expression_system_cell_line: Schneiders S2 cells
expression_system_vector_type: plasmid
Authors : Motlova, L., Novakova, Z., Barinka, C.
Keywords : glutamate carboxypeptidase II (GCPII); NAALADase; prostate-specific membrane antigen; urea based inhibitor, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a urea based inhibitor PSMA 1023

Motlova, L.,Novakova, Z.,Barinka, C.
To Be Published 

Reaction

Chain : A
UniProt : Q04609 (FOLH1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. 3.4.17.21 -
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