Brand  (β version)

PDB ID: 5O56

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Ligands
Code Name Style Show Link
9L8 (2~{R},3~{S},4~{R},5~{R},6~{R})-5-azanyl-2-(hydroxymethyl)-6-(3-naphthalen-2-yl-1~{H}-1,2,4-triazol-5-yl)oxane-3,4-diol PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 5O56   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Glycogen Phosphorylase B in complex with 29b
Release Data : 2017-09-27
Compound :
mol_id molecule chains synonym
1 Glycogen phosphorylase, muscle form A Myophosphorylase
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
Authors : Solovou, T.G.A., Kyriakis, E., Stravodimos, G.A., Kantsadi, A.L., Chatzileontiadou, D.S., Skamnaki, V.T., Leonidas, D.D.
Keywords : Transferase
Exp. method : X-RAY DIFFRACTION ( 2.45 Å )
Citation :

Nanomolar Inhibitors of Glycogen Phosphorylase Based on beta-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.

Bokor, E.,Kyriakis, E.,Solovou, T.G.A.  et al.
(2017)  J. Med. Chem.  60 : 9251 - 9262

PubMed: 28925695
DOI: 10.1021/acs.jmedchem.7b01056

Reaction

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
left-to-right
Cofactor: Evidence: Note:
pyridoxal 5'-phosphate ECO:0000269 | PubMed:7500360
ECO:0000269 | PubMed:8976550
ECO:0007744 | PDB:2PRI
ECO:0007744 | PDB:2SKC
ECO:0007744 | PDB:2SKD
ECO:0007744 | PDB:2SKE
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