Het-PDB Navi2 (PDB: 5O4A)

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Ligands
Code	Name	Link
SO4	Sulfate ion	PoSSuM
GOL	Glycerol	PoSSuM
9K8	[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 4-ethyl-3-fluorosulfonyl-benzoate	PoSSuM

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Download interaction data: 5O4A

Code :

5O4A PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Human FGF in complex with a covalent inhibitor

Release Data :

2018-02-07

Compound :

mol_id	molecule	chains	synonym
1	Fibroblast growth factor receptor 1	A,B	FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
	ec: 2.7.10.1 fragment: UNP residues 458-765

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR

Authors :

Debreczeni, J., Breed, J., Mukherjee, H., Aquila, B., Kaiser, C., Tentarelli, S., Whitty, A., Grimster, N.

Keywords :

FGFR Fibroblast Growth Factor, covalent inhibition, FGFR Fibroblast Grwth Fctr RTK, transferase

Exp. method :

X-RAY DIFFRACTION ( 2.01 Å )

Citation :

A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.

Mukherjee, H.,Debreczeni, J.,Breed, J. et al.
(2017) Org. Biomol. Chem. 15 : 9685 - 9695

Chain :

A, B

UniProt :

P11362 (FGFR1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:1379697, PubMed:15117958, PubMed:18480409, PubMed:19224897, PubMed:19665973, PubMed:20133753, PubMed:8622701
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PDB ID: 5O4A