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Ligands
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9J8 (2~{R})-2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-~{N}-ethyl-pent-4-enamide
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Code : 5O3G   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Human Brd2(BD2) mutant in complex with AL-Am1
Release Data : 2018-02-14
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 2 A,B O27.1.1,Really interesting new gene 3 protein
mutation: L383V
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
gene: BRD2, KIAA9001, RING3
expression_system_plasmid: pNIC28-Bsa4
Authors : Chan, K.-H., Runcie, A.C., Ciulli, A.
Keywords : The Bromodomain and Extra-Terminal Domain (BET) Family Chromatin binding protein, transcription
Exp. method : X-RAY DIFFRACTION ( 1.850 Å )
Citation :

Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition.

Runcie, A.C.,Zengerle, M.,Chan, K.H.  et al.
(2018)  Chem Sci  9 : 2452 - 2468

PubMed: 29732121
DOI: 10.1039/c7sc02536j

Chain : A, B
UniProt : P25440 (BRD2_HUMAN)
Reaction : -