Het-PDB Navi2 (PDB: 5O3C)

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Ligands
Code	Name	Link
9J2	Methyl (2~{R})-2-[(4~{S})-6-(4-chlorophenyl)-9-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]propanoate	PoSSuM
CL	Chloride ion	PoSSuM
DQW	(2~{S})-1-[(2~{S})-2-oxidanylpropoxy]propan-2-ol	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5O3C

Code :

5O3C PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Human Brd2(BD2) mutant in complex with 9-Me

Release Data :

2018-02-14

Compound :

mol_id	molecule	chains	synonym
1	Bromodomain-containing protein 2	A	O27.1.1,Really interesting new gene 3 protein
	mutation: L383V

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: BRD2, KIAA9001, RING3 expression_system_plasmid: pNIC28-Bsa4

Authors :

Runcie, A.C., Chan, K.-H., Ciulli, A.

Keywords :

The Bromodomain and Extra-Terminal Domain (BET) Family Chromatin binding protein, TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 1.600 Å )

Citation :

Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition.

Runcie, A.C.,Zengerle, M.,Chan, K.H. et al.
(2018) Chem Sci 9 : 2452 - 2468

PDB ID: 5O3C