Brand  (β version)

PDB ID: 5O2D

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Ligands
Code Name Style Show Link
9HH ~{N}-[2-(9~{H}-carbazol-1-yl)phenyl]methanesulfonamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5O2D   PDBj   RCSB PDB   PDBe
Header : ADP-RIBOSE-BINDING-PROTEIN
Title : PARP14 Macrodomain 2 with inhibitor
Release Data : 2017-11-08
Compound :
mol_id molecule chains synonym
1 Poly [ADP-ribose] polymerase 14 A PARP-14,ADP-ribosyltransferase diphtheria toxin-like 8,ARTD8,B aggressive lymphoma protein 2
ec: 2.4.2.30
mutation: K1048S,K1154S,K1158S,K1162S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PARP14, BAL2, KIAA1268
expression_system_vector_type: plasmid
expression_system_plasmid: pNIC28-Bsa4
Authors : Uth, K., Schuller, M., Sieg, C., Wang, J., Krojer, T., Knapp, S., Riedels, K., Bracher, F., Edwards, A.M., Arrowsmith, C., Bountra, C., Elkins, J.M., Structural Genomics Consortium (SGC)
Keywords : PARP, ADP-ribose, Structural Genomics, Structural Genomics Consortium, SGC, ADP-RIBOSE-BINDING-PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.

Schuller, M.,Riedel, K.,Gibbs-Seymour, I.  et al.
(2017)  ACS Chem. Biol.  12 : 2866 - 2874

PubMed: 28991428
DOI: 10.1021/acschembio.7b00445

Reaction

Chain : A
UniProt : Q460N5 (PAR14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - PubMed:27796300
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