Het-PDB Navi2 (PDB: 5O22)

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Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
C3R	Carolacton				PoSSuM

Non-standard Residues
Code	Name	Show
MLY	N-dimethyl-lysine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5O22

Code :

5O22 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

E. coli FolD in complex with carolacton

Release Data :

2018-02-28

Compound :

mol_id	molecule	chains
1	Bifunctional protein FolD	A
	ec: 1.5.1.5,3.5.4.9 other_details: Lysines reductively methylated

mol_id	molecule	chains
2	Bifunctional protein FolD	B
	ec: 1.5.1.5,3.5.4.9

mol_id	molecule	chains
3	Bifunctional protein FolD	C
	ec: 1.5.1.5,3.5.4.9

mol_id	molecule	chains
4	Bifunctional protein FolD	D
	ec: 1.5.1.5,3.5.4.9

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (strain K12) (taxid:83333)	Escherichia coli BL21(DE3) (taxid:469008)
	strain: K12 gene: folD, ads, b0529, JW0518

mol_id	organism_scientific	expression_system
2	Escherichia coli (strain K12) (taxid:83333)	Escherichia coli BL21(DE3) (taxid:469008)
	strain: K12 gene: folD, ads, b0529, JW0518

mol_id	organism_scientific	expression_system
3	Escherichia coli (strain K12) (taxid:83333)	Escherichia coli BL21(DE3) (taxid:469008)
	strain: K12 gene: folD, ads, b0529, JW0518

mol_id	organism_scientific	expression_system
4	Escherichia coli (strain K12) (taxid:83333)	Escherichia coli BL21(DE3) (taxid:469008)
	strain: K12 gene: folD, ads, b0529, JW0518

Authors :

Koehnke, J., Sikandar, A.

Keywords :

carolacton, FolD, natural product, inhibitor, oxidoreductase

Exp. method :

X-RAY DIFFRACTION ( 2.100 Å )

Citation :

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD.

Fu, C.,Sikandar, A.,Donner, J. et al.
(2017) Nat Commun 8 : 1529 - 1529

PDB ID: 5O22