Brand  (β version)

PDB ID: 5O1S

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Ligands
Code Name Style Show Link
9HB Dimethyl fumarate PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5O1S   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
Release Data : 2018-05-30
Compound :
mol_id molecule chains synonym
1 Ribosomal protein S6 kinase alpha-3 A S6K-alpha-3,90 kDa ribosomal protein S6 kinase 3,p90RSK3,MAP kinase-activated protein kinase 1b,MAPKAPK-1b,Ribosomal S6 kinase 2,RSK-2,pp90RSK2
ec: 2.7.11.1
fragment: UNP residues 400-740
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Rps6ka3, Mapkapk1b, Rps6ka-rs1, Rsk2
Authors : Andersen, J.L., Nissen, P.
Keywords : Covalent, Inhibitor, Kinase, allosteric, transferase
Exp. method : X-RAY DIFFRACTION ( 1.900 Å )
Citation :

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases.

Andersen, J.L.,Gesser, B.,Funder, E.D.  et al.
(2018)  Nat Commun  9 : 4344 - 4344

PubMed: 30341347
DOI: 10.1038/s41467-018-06787-w

Reaction

Chain : A
UniProt : P18654 (KS6A3_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:15109498
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 -
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