Brand  (β version)

PDB ID: 5O1N

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Ligands
Code Name Style Show Link
9H8 1,1,1-tris(fluoranyl)-~{N}-[[(2~{S})-pyrrolidin-2-yl]methyl]methanesulfonamide PoSSuM
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
Non-standard Residues
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Structure summary

Code : 5O1N   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide bound
Release Data : 2017-05-31
Compound :
mol_id molecule chains synonym
1 Alpha-aminoadipic semialdehyde synthase, mitochondrial A LKR/SDH
ec: 1.5.1.8,1.5.1.9
fragment: UNP residues 455-926
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: AASS
expression_system_common: Fall armyworm
expression_system_cell_line: SF9
expression_system_plasmid: pFB-LIC-Bse
Authors : Kopec, J., Rembeza, E., Pena, I.A., Strain-Damerell, C., Goubin, S., Sethi, R., Velupillai, S., Talon, R., Collins, P., Krojer, T., McLaughlin, M., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., von Delft, F., Arruda, P., Yue, W.W.
Keywords : human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide bound, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.28 Å )
Citation :

Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide bound

Kopec, J.,Yue, W.W.
To Be Published 

Reaction

Chain : A
UniProt : Q9UDR5 (AASS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + L-saccharopine + NADP(+) = 2-oxoglutarate + H(+) + L- lysine + NADPH 1.5.1.8 PubMed:10775527, PubMed:463877
right-to-left PubMed:10775527
H2O + L-saccharopine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH 1.5.1.9 PubMed:10775527, PubMed:463877
left-to-right PubMed:10775527