Brand  (β version)

PDB ID: 5O1I

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
9GH 2-(diethylamino)-6-iodanyl-5-oxidanyl-7-pyrrol-1-yl-1,3-benzothiazole-4-carboxylic acid PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 5O1I   PDBj   RCSB PDB   PDBe
Header : DNA BINDING PROTEIN
Title : p53 cancer mutant Y220C in complex with compound MB710
Release Data : 2018-05-09
Compound :
mol_id molecule chains synonym
1 Cellular tumor antigen p53 A,B Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
fragment: UNP residues 94-312
mutation: M133L, V203A, Y220C, N239Y, N268D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TP53, P53
Authors : Joerger, A.C., Baud, M.G.J., Bauer, M.R., Fersht, A.R.
Keywords : p53, tumor suppressor, cancer mutation, protein stabilization, small-molecule stabilizers, cancer therapy, DNA binding protein, molecular chaperones
Exp. method : X-RAY DIFFRACTION ( 1.400 Å )
Citation :

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.

Baud, M.G.J.,Bauer, M.R.,Verduci, L.  et al.
(2018)  Eur J Med Chem  152 : 101 - 114

PubMed: 29702446
DOI: 10.1016/j.ejmech.2018.04.035

Reaction

Chain : A, B
UniProt : P04637 (P53_HUMAN)
Reaction : -
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:14534297
ECO:0000269 | PubMed:16793544
ECO:0000269 | PubMed:17015838
ECO:0000269 | PubMed:18650397
ECO:0000269 | PubMed:19515728
ECO:0000269 | PubMed:20142040
ECO:0000269 | PubMed:20364130
Binds 1 zinc ion per subunit.