PDB ID: 5O1I
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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ZN | Zinc ion | PoSSuM | |||
9GH | 2-(diethylamino)-6-iodanyl-5-oxidanyl-7-pyrrol-1-yl-1,3-benzothiazole-4-carboxylic acid | PoSSuM | |||
EDO | 1,2-ethanediol | PoSSuM |
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Download interaction data: 5O1I
Structure summary
Code : | 5O1I PDBj RCSB PDB PDBe | ||||||||||||
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Header : | DNA BINDING PROTEIN | ||||||||||||
Title : | p53 cancer mutant Y220C in complex with compound MB710 | ||||||||||||
Release Data : | 2018-05-09 | ||||||||||||
Compound : |
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Source : |
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Authors : | Joerger, A.C., Baud, M.G.J., Bauer, M.R., Fersht, A.R. | ||||||||||||
Keywords : | p53, tumor suppressor, cancer mutation, protein stabilization, small-molecule stabilizers, cancer therapy, DNA binding protein, molecular chaperones | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.400 Å ) | ||||||||||||
Citation : |
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Baud, M.G.J.,Bauer, M.R.,Verduci, L.
et al.
PubMed: 29702446 |
Reaction
Chain : | A, B |
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UniProt : | P04637 (P53_HUMAN) |
Reaction : | - |