PDB ID: 5NZP
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Structure summary
Code : | 5NZP PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-Hydroxybenzisoxazole | ||||||||||||
Release Data : | 2017-06-14 | ||||||||||||
Compound : |
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Source : |
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Authors : | Unterlass, J.E., Basle, A., Blackburn, T.J., Tucker, J., Cano, C., Noble, M.E.M., Curtin, N.J. | ||||||||||||
Keywords : | dehydrogenase, serine metabolism, FBDD, oxidoreductase | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.30 Å ) | ||||||||||||
Citation : |
Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Unterlass, J.E.,Basle, A.,Blackburn, T.J.
et al.
PubMed: 29568346 |
Reaction
Chain : | B, A | ||||||||||||||||
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UniProt : | O43175 (SERA_HUMAN) | ||||||||||||||||
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