PDB ID: 5NXE
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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SO4 | Sulfate ion | PoSSuM | |||
ZN | Zinc ion | PoSSuM | |||
9D5 | 2-[4-[2-hydroxyethyl(methyl)amino]phenyl]-2,3-dihydro-1~{H}-quinazolin-4-one | PoSSuM | |||
GOL | Glycerol | PoSSuM |
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Download interaction data: 5NXE
Structure summary
Code : | 5NXE PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | TRANSFERASE | ||||||||||||||||||||||||
Title : | Crystal structure of TNKS2 in complex with 2-{4-[(2-hydroxyethyl)(methyl)amino]phenyl}-1,2,3,4-tetrahydroquinazolin-4-one | ||||||||||||||||||||||||
Release Data : | 2018-03-21 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Nkizinkiko, Y., Haikarainen, T., Lehtio, L. | ||||||||||||||||||||||||
Keywords : | Tankyrase, Inhibitor, ARTD6, PARP5b, ADP-ribosyltransferase, TRANSFERASE | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.60 Å ) | ||||||||||||||||||||||||
Citation : |
2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
Nkizinkiko, Y.,Desantis, J.,Koivunen, J.
et al.
PubMed: 29374194 |
Reaction
Chain : | H, I | ||||||||||||||||
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UniProt : | Q9H2K2 (TNKS2_HUMAN) | ||||||||||||||||
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